Key result
A simple, accurate, and precise first order derivative spectrophotometric method was successfully developed and validated for the simultaneous estimation of clopidogrel bisulphate and aspirin in tablets.
A simple and accurate first derivative spectrophotometric method was developed for the simultaneous estimation of clopidogrel and aspirin in tablets.
Offers validated method for simultaneous tablet analysis; leaves open routine adoption pending comparative studies.
A simple, accurate and precise spectrophotometric method has been developed for simultaneous estimation of clopidogrel bisulphate and aspirin by employing first order derivative zero crossing method. The first order derivative absorption at 232.5 nm (zero cross point of aspirin) was used for clopidogrel bisulphate and 211.3 nm (zero cross point of clopidogrel bisulphate) for aspirin.Both the drugs obeyed linearity in the concentration range of 5.0 μg/ml to 25.0 μg/ml (correlation coefficient r(2)<1). No interference was found between both determined constituents and those of matrix. The method was validated statistically and recovery studies were carried out to confirm the accuracy of the method.
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Game et al. (2010) studied this question. First derivative spectrophotometric method was evaluated on Simultaneous estimation of clopidogrel bisulphate and aspirin in tablets. A simple, accurate, and precise first order derivative spectrophotometric method was successfully developed and validated for the simultaneous estimation of clopidogrel bisulphate and aspirin in tablets.
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