Key result
Reverse phase HPLC with isocratic elution successfully determines aspirin and clopidogrel in combined dosage forms.
The study provides a validated HPLC method for the simultaneous quantification of aspirin and clopidogrel in combined tablet formulations.
May aid quality control of combined antiplatelet tablets; leaves open extension to bioanalysis or regulatory use.
A reverse phase high performance liquid chromatographic method to determine aspirin and clopidogrel in combined dosage form is proposed. The chromatographic resolution of aspirin and clopidogrel was obtained in a mobile phase consisting of 0.1% v/v triethylamine (pH 4.0):acetonitrile in the ratio 25:75% (v/v) in an isocratic elution. A detection wavelength of 225 nm and flow rate of 1 ml/min was used in the study. Nimesulide (20 µg/ml) was used as an internal standard. The system suitability procedures as precision, accuracy, LOD, LOQ, number of theoretical plates and tailing factor were studied.
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Gandhimathi et al. (2007) studied this question. Reverse phase high performance liquid chromatographic method was evaluated on Chromatographic resolution of aspirin and clopidogrel. A reverse phase high performance liquid chromatographic method was successfully developed to determine aspirin and clopidogrel in combined dosage form using an isocratic elution.
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