Key result
UV spectrophotometric method accurately quantifies aspirin in tablets with 99.8% recovery.
A simple and cost-effective UV spectrophotometric method was successfully developed and validated for quantifying aspirin in pharmaceutical formulations and biological fluids.
May offer accessible aspirin assay in resource-limited settings; leaves open comparative validation against reference methods.
A simple, sensitive, specific, precise and cost effective UV spectrophotometric EMC-11 was used to developed and validated method for determination of Aspirin (ASP) in pharmaceutical formulation and biological fluid. The maximum absorption of Aspirin was shown at 300 nm using methanol as a solvent. The linear calibration curve of aspirin concentrations range (10-80 ppm) are shown to show the regression equation (Y= 0.0409x + 0.0015), and correlation Coefficient (R2 = 0.9995). %RSD showed an acceptable value for precision study less than 1%. Where LOD and LOQ value showed to be μg/mL and μg/mL, respectively. LOD and LOQ were found to be 0.02 and 0.08, respectively. Accuracy study showed good recovery 99.8% in locally commercial tablets. The present developed method was successfully applied for stability-indicating of Aspirin in pure and tablets dosage form. Stability-indicating study was investigated under acidic, alkaline, oxidative, photolytic and thermal conditions. According to the resultants it can be concluded that the validated method can be used in routine analysis of Aspirin in tablets dosage form, biological fluid and degradation study.
No takes yet. Share an insight, caveat, or question.
Fattah et al. (2025) studied this question. UV spectrophotometric EMC-11 method was evaluated on Method validation parameters (linearity, precision, accuracy, LOD, LOQ). A UV spectrophotometric method was successfully developed and validated for the quantification of Aspirin in tablets, demonstrating high accuracy (99.8% recovery) and precision (RSD < 1%).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: