Key result
Hyperdynamic left ventricular ejection fraction (≥70%) during COVID-19 hospitalization was associated with increased 60-day mortality compared to reduced LVEF (aOR 3.34; 95% CI 1.39-8.42; p<0.01).
Why the study?
To compare the characteristics and outcomes of COVID-19 patients with hyperdynamic LVEF to those with normal or reduced LVEF.
Does hyperdynamic LVEF increase the risk of 60-day mortality in adult patients hospitalized with COVID-19?
Cohort (n=419)
No
Does hyperdynamic LVEF increase the risk of 60-day mortality in adult patients hospitalized with COVID-19?
Answers are grounded in this paper and cite their sources.
In patients hospitalized with COVID-19, a hyperdynamic LVEF (≥70%) on admission echocardiogram is associated with a significantly increased risk of 60-day mortality and critical illness.
Study objective: To compare the characteristics and outcomes of COVID-19 patients with a hyperdynamic LVEF (HDLVEF) to those with a normal or reduced LVEF. Design: Retrospective study. Setting: Rush University Medical Center. Participants: Of the 1682 adult patients hospitalized with COVID-19, 419 had a transthoracic echocardiogram (TTE) during admission and met study inclusion criteria. Interventions: Participants were divided into reduced (LVEF < 50%), normal (≥50% and <70%), and hyperdynamic (≥70%) LVEF groups. Main outcome measures: LVEF was assessed as a predictor of 60-day mortality. Logistic regression was used to adjust for age and BMI. The HDLVEF group was also at higher risk for 60-day mortality than the reduced LVEF group (aOR 3.34 [CI: 1.39-8.42]; p < 0.01). Conclusion: The presence of hyperdynamic LVEF during a COVID-19 hospitalization was associated with an increased risk of 60-day mortality, the requirement for mechanical ventilation, vasopressors, and intensive care unit.
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Rahman et al. (2022) conducted a cohort in COVID-19 (n=419). Hyperdynamic LVEF (≥70%) vs. Normal (≥50% and <70%) and reduced (<50%) LVEF was evaluated on 60-day mortality (aOR 3.34, 95% CI 1.39-8.42, p=< 0.01). Hyperdynamic left ventricular ejection fraction (≥70%) during COVID-19 hospitalization was associated with increased 60-day mortality compared to reduced LVEF (aOR 3.34; 95% CI 1.39-8.42; p<0.01).
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