Key result
In a patient with anthracycline-induced cardiomyopathy, cardiomyocyte diameter increased and systolic function markedly decreased 5 years after left ventricular assist device explantation.
Case Report (n=1)
No
Pathological changes in the myocardium, such as increased cardiomyocyte diameter, may precede echocardiographic evidence of cardiac dysfunction in patients with reworsening heart failure after LVAD explantation.
Pathological changes post-LVAD explant in one case should not alter practice; leaves open fibrosis dynamics in anthracycline cardiomyopathy recovery.
We herein report the long-term changes in cardiac function and pathological findings after successful explantation of a left ventricular assist device in a 42-year-old patient with anthracycline-induced cardiomyopathy with reworsening heart failure. Endomyocardial biopsy samples revealed that the cardiomyocyte diameter decreased and collagen volume fraction increased just after left ventricular assist device explantation. The collagen volume fraction decreased after 6 months, despite preserved systolic function. At 5 years after left ventricular assist device explantation, the systolic function markedly decreased and cardiomyocyte diameter increased. Pathological changes of the myocardium may enable the identification of cardiac dysfunction prior to echocardiographic changes in patients with reworsening heart failure after left ventricular assist device explantation.
No takes yet. Share an insight, caveat, or question.
Hiraiwa et al. (2020) conducted a case report in Anthracycline-induced cardiomyopathy (n=1). Left ventricular assist device explantation was evaluated on Cardiomyocyte diameter and collagen volume fraction. In a patient with anthracycline-induced cardiomyopathy, cardiomyocyte diameter increased and systolic function markedly decreased 5 years after left ventricular assist device explantation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: