Key result
ProBNP levels did not significantly change after continuous renal replacement therapy (23,306 vs 22,178 pg/mL, p=0.756) and showed no correlation with fluid load in pediatric patients.
Why the study?
Is pro-BNP a reliable marker for evaluating fluid load in pediatric patients undergoing continuous renal replacement therapy?
Observational (n=28)
No
Is pro-BNP a reliable marker for evaluating fluid load in pediatric patients undergoing continuous renal replacement therapy?
Absolute Event Rate: 22178.07% vs 23306.21%
p-value: p=0.756
Pro-BNP is not a reliable marker for evaluating accumulated fluid load or the amount of fluid removed in pediatric patients undergoing continuous renal replacement therapy.
Caution against relying on pro-BNP for fluid assessment in pediatric CRRT; Level 3 data leaves open the need for validated markers.
Ama: Pro-B tipi natriretik peptid (Pro-BNP), hemodiyaliz hastalarnda volm marker olarak tanmlanmtr. Bu almay yapmaktaki amacmz; overhydration nedeniyle continue renal replasman therapy (CRRT) uygulanan hastalarda, serum pro-BNP deerinin sv ykn belirlemedeki roln deerlendirmektir. Gere ve Yntem: 3.dzey 7 yatakl ocuk Youn Bakm nitesi'ne yatan, overhydration nedeniyle CRRT uygulanan hastalar alma almaya alnd. Bulgular: alma; 15'i kz (%53.6), 13' erkek (%46.4) toplam 28 hasta ile yapld. Ortalama yalar 61.4656.13 ay (min.2 -max.183 ), CRRT uygulama sresi ortalama 20.814.9 saat (min.5, max.60), ekilen sv yzdesi ise ortalama %8. 43 4.51'di (min.2.5, max.20) idi. CRRT ilemi hastalarn 12'sine(%42.9) sv yk, 16'sna(%57.1) sv yk ve elik eden remi nedeniyle uyguland. Hastalarn balang ve biti vcut arl, re, kreatin deerleri arasnda istatistiksel olarak anlaml bir fark saptand(p:0.001). CRRT balamadan hemen nce baklan ortalama proBNP 23.306 13.943 pg/ml, CRRT bitiminde baklan ortalama proBNP 22.178 15.473 pg/ml bulundu. Balang Pro-BNP ile biti Pro-BNP dzeyleri arasnda anlaml bir fark saptanmad(p:0.756). Hastalarn biti Pro-BNP deerleri ile biti vcut arl, re, kreatin, sodyum arasnda da, serum sodyum dzeyi dnda bir korelasyon yoktu(p>0.05). ). Benzer ekilde balang Pro-BNP deerleri ile sv yk arasnda (p:0.602) ve ekilen sv yzdesi ile biti pro-BNP deerleri arasnda (p:0.155) da korelasyon yoktu. Tartma: Sv yk nedeniyle CVVHDF uygulanan hastalarn, sv ykleri ile balang pro-BNP deerleri arasnda ve uygulama bitiminde ekilen sv yzdesi ile biti pro-BNP deerleri arasnda iliki saptanmad. Biriken sv yk ve ekilen sv miktarn deerlendirmede uygun bir belirte olmad sonucuna varld.
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Seher Erdoğan (2016) conducted an observational in Overhydration requiring CRRT (n=28). Continuous Renal Replacement Therapy (CRRT) vs. Pre-CRRT baseline was evaluated on Change in proBNP levels before and after CRRT (p=0.756). ProBNP levels did not significantly change after continuous renal replacement therapy (23,306 vs 22,178 pg/mL, p=0.756) and showed no correlation with fluid load in pediatric patients.
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