Key result
NT-pro-BNP levels were positively correlated with creatinine and negatively correlated with glomerular filtration rate in patients with compensated chronic kidney disease.
Why the study?
The study was conducted to evaluate the role of NT-pro-BNP in assessing hypervolemia in chronic kidney disease and to examine its relationship with CKD.
Does NT-pro BNP correlate with markers of hypervolemia and renal function in patients with compensated chronic kidney disease?
Cross-Sectional (n=60)
No
Does NT-pro BNP correlate with markers of hypervolemia and renal function in patients with compensated chronic kidney disease?
NT-pro BNP levels correlate significantly with markers of renal function and hypervolemia in compensated CKD, suggesting its utility in assessing volume status as CKD progresses.
Answers are grounded in this paper and cite their sources.
NT-proBNP may aid hypervolemia evaluation in compensated CKD; hypothesis-generating and should not change practice without prospective validation.
Aim: To evaluate the role of N-terminal pro b-type natriuretic peptide (NT-pro-BNP) in the evaluation of hypervolemia in chronic kidney disease (CKD) and its relationship with CKD. Methods: Sixty compensated chronic kidney disease patients enrolled in this study. NT-pro BNP levels and other routine biochemical laboratory parameters are studied. The associations between results were analyzed. Results: NT-pro BNP levels were correlated with urea (r = 0.66, p <0.01), creatinine (r = 0.69, p <0.01) and phosphorus (r = 0.36, p <0.01) values and were negative correlated with hemoglobin (r = -0.32, p = 0.01), hematocrit (r = -0.36, p <0.01), albumin (r = -0.29, p = 0.02) and glomerular filtration rate (GFR) values (r = -0.35, p <0.01).
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Duman et al. (2020) conducted a cross-sectional in Compensated chronic kidney disease (n=60). NT-pro-BNP levels was evaluated on Correlation between NT-pro-BNP levels and serum creatinine (r = 0.69, p=<0.01). NT-pro-BNP levels were positively correlated with creatinine and negatively correlated with glomerular filtration rate in patients with compensated chronic kidney disease.
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