Key result
ANGPTL2 mRNA levels in formalin-fixed paraffin-embedded tissues accurately predicted vascular invasion in gastric cancer, demonstrating an area under the curve of 0.92.
Why the study?
Does ANGPTL2 mRNA level in FFPE tissues identify cancerous areas and correlate with vascular invasion in patients with gastric cancer?
Cross-Sectional (n=15)
No
Does ANGPTL2 mRNA level in FFPE tissues identify cancerous areas and correlate with vascular invasion in patients with gastric cancer?
Effect estimate: AUC 0.92 (95% CI 0.78-1.00)
p-value: p=0.01
ANGPTL2 mRNA levels in FFPE tissues may serve as a biomarker for diagnosing gastric cancer and predicting vascular invasion.
ANGPTL2 mRNA levels may support gastric cancer biomarker development; hypothesis-generating and requires prospective validation before clinical use.
With the recent advances in medical technologies, gastric cancer can often be removed with minimally invasive surgical techniques when identified early. Surgery must remove all gastric cancer, since residual cancerous tissue may lead to recurrence. Resected cancerous tissues are pathologically evaluated to determine whether all cancerous areas have been removed, but such assessments are rarely straightforward, and cancer markers could inform such pathological evaluations of cancer. An ideal marker would be identifiable in formalin‑fixed paraffin‑embedded (FFPE) tumor tissue. The first objective of the present study was to compare levels of angiopoietin‑like protein 2 (ANGPTL2) in cancerous and noncancerous areas of FFPE tissues to determine whether ANGPTL2 is a marker relevant to the pathological diagnosis of cancer. The second objective was to evaluate whether ANGPTL2 mRNA is useful as a marker of the extent of vascular invasion of gastric cancer. Out of the 15 patients studied, 12 had a higher ANGPTL2 mRNA levels in cancerous areas compared with noncancerous areas. This finding indicated that ANGPTL2 mRNA is useful as a biomarker for identifying cancerous areas in FFPE tissues, at least for male patients. Spearman's rank correlation analysis showed a significant correlation between the ANGPTL2 mRNA level and the degree of vascular invasion of cancer (r=0.66; P=0.01). In receiver operating characteristic curve analysis of the association between the ANGPTL2 mRNA level and the degree of vascular invasion, the area under the curve was 0.92 (95% confidence interval, 0.78‑1.00; P=0.01), indicating a significant association. The present study demonstrates that ANGPTL2 mRNA in FFPE tissues is a potential biomarker that informs the pathological diagnosis of gastric cancer and that ANGPTL2 mRNA may be predictive of vascular invasion, which is an indicator of metastasis in gastric cancer.
No takes yet. Share an insight, caveat, or question.
Yoshinaga et al. (2018) conducted a cross-sectional in Gastric cancer (n=15). ANGPTL2 mRNA level vs. Noncancerous tissue / low ANGPTL2 mRNA level was evaluated on Diagnostic accuracy of ANGPTL2 mRNA level for vascular invasion (AUC 0.92, 95% CI 0.78-1.00, p=0.01). ANGPTL2 mRNA levels in formalin-fixed paraffin-embedded tissues accurately predicted vascular invasion in gastric cancer, demonstrating an area under the curve of 0.92.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: