Key result
Methanethiosulfonate compounds decreased ryanodine receptor channel conductance in a step-wise, irreversible, and cumulative manner from the cytoplasmic side when the channel was open.
MTS compounds inhibit current through the ryanodine receptor by covalently modifying the open channel from the cytoplasmic side, providing functional markers for specific residues.
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Identifies MTS compounds as open-channel RyR modifiers; leaves open any therapeutic translation in human cardiac disease.
Quinn et al. (1997) studied this question. Methanethiosulfonate (MTS) compounds was evaluated on Channel conductance. Methanethiosulfonate compounds decreased ryanodine receptor channel conductance in a step-wise, irreversible, and cumulative manner from the cytoplasmic side when the channel was open.
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