Key result
The Pfizer COVID-19 vaccine was associated with a 0.026% prevalence of delayed vasovagal reaction with reflex syncope, compared to 0% among historical influenza vaccine recipients.
Why the study?
COVID-19 vaccine side effects, such as syncope mimicking sudden cardiac death, are serious clinical concerns.
Does COVID-19 vaccination increase the risk of delayed vasovagal syncope compared to influenza vaccination?
Case Report (n=42,916)
No
Does COVID-19 vaccination increase the risk of delayed vasovagal syncope compared to influenza vaccination?
Absolute Event Rate: 0.026% vs 0%
COVID-19 vaccination is associated with a very rare risk (0.026%) of delayed vasovagal syncope, which medical staff should be aware of to prevent misdiagnosis.
Rare delayed VVR after COVID-19 vaccination suggests minimal risk; leaves open need for prospective studies to confirm incidence and causality.
Coronavirus disease 2019 (COVID-19) has become a pandemic, and vaccines remain the only effective tools available for ending it. However, their side effects, such as syncope, which mimics sudden cardiac death, are serious concerns. We herein report 6 cases of delayed vasovagal syncope and presyncope (VVR) caused by COVID-19 vaccination among 25,530 COVID-19 patients. The prevalence of delayed VVR due to COVID-19 vaccination was 0.026%. In addition, no delayed VVR was found among 17,386 patients who received the influenza vaccine. Delayed VVR is likely to be overlooked if medical staff are not aware of this symptom. This report provides significant information regarding effects of COVID-19 vaccination.
No takes yet. Share an insight, caveat, or question.
Takase et al. (2022) conducted a case report in Delayed vasovagal reaction with reflex syncope (n=42,916). Pfizer COVID-19 vaccine vs. Influenza vaccine was evaluated on Prevalence of delayed vasovagal reaction (VVR). The Pfizer COVID-19 vaccine was associated with a 0.026% prevalence of delayed vasovagal reaction with reflex syncope, compared to 0% among historical influenza vaccine recipients.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: