Why the study?
Does intracerebroventricular injection of GABA reduce blood pressure and sympathetic nerve activity in spontaneously hypertensive rats?
Population
Spontaneously hypertensive rats and normotensive Wistar/Wistar Kyoto rats, anesthetized with urethane
Comparison
Intracerebroventricular injections of GABA vs Normotensive Wistar Kyoto controls and baseline…
Design
Preclinical
Authors
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Hypothesis-generating for central GABA targets in hypertension; extends rodent models but leaves human translation open.
Does intracerebroventricular injection of GABA reduce blood pressure and sympathetic nerve activity in spontaneously hypertensive rats?
Centrally injected GABA decreases sympathetic nerve activity, lowering blood pressure and heart rate, and reverses hypothalamo-sympathetic hyperactivity in spontaneously hypertensive rats.
Sasaki et al. (1986) studied this question.
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