Key result
A recombinant HSV-1 harboring a non-classical NLS mutation in VP19C replicates less efficiently than wild-type, indicating nuclear import of VP19C is required for efficient HSV-1 production.
Population
Herpes simplex virus type 1 (HSV-1) VP19C protein
Comparison
NLS mutation (NLSm) vs Wild-type HSV-1
Design
Preclinical
Authors
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VP19C nuclear import may be explored as an HSV-1 antiviral target; leaves open translation from animal models to clinical relevance.
Identification of a novel non-classical NLS of VP19C required for efficient HSV-1 production.
Li et al. (2012) studied Herpes simplex virus type 1 (HSV-1). NLS mutation (NLSm) in VP19C vs. Wild-type HSV-1 was evaluated on Viral replication efficiency. A recombinant HSV-1 harboring a non-classical NLS mutation in VP19C replicates less efficiently than wild-type, indicating nuclear import of VP19C is required for efficient HSV-1 production.
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