Key result
The nuclear import of HSV-1 UL31 was characterized to be dependent on Ran-, importin α1- and transportin-1-mediated pathways.
The study identifies the Ran-, importin α1-, and transportin-1-mediated pathways as the mechanisms for HSV-1 UL31 nuclear translocation.
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As an important protein, UL31 has been demonstrated to play multiple roles in herpes simplex virus 1 (HSV-1) replication. Previous studies showed that UL31 predominantly locates in the nucleus in chemical fixed cells and live cells, however, the determining mechanisms for its nuclear translocation is not clear. In the present study, by utilizing live cells fluorescent microscopy and co-immunoprecipitation assays, the nuclear import of UL31 was characterized to be dependent on Ran-, importin α1- and transportin-1-mediated pathway. Therefore, these results will promote the understanding of UL31-mediated biological functions in HSV-1 infection cycle.
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Elucidates HSV-1 nuclear trafficking in animal models; leaves open whether importin inhibition yields antiviral strategies.
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Cai et al. (2016) studied Herpes simplex virus 1 (HSV-1) infection. HSV-1 UL31 protein was evaluated on Nuclear import mechanism. The nuclear import of HSV-1 UL31 was characterized to be dependent on Ran-, importin α1- and transportin-1-mediated pathways.
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