Key result
In three different cell lines, simultaneous expression of AT1R and B2R did not result in functional modulation or physical interaction between the two receptor proteins.
Population
COS-7, HEK293, and NIH3T3 cell lines
Design
Preclinical
Authors
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No support for AT1R-B2R interaction in cell lines; challenges prior heterodimer claims and leaves in vivo relevance open.
This study refutes previous claims that AT1R and B2R form constitutive heterodimers and that B2R potentiates AT1R signaling.
Hansen et al. (2008) studied AT1R/B2R heterodimerization. Simultaneous expression of AT1R and B2R was evaluated on Functional modulation by or physical interaction between AT1R and B2R. In three different cell lines, simultaneous expression of AT1R and B2R did not result in functional modulation or physical interaction between the two receptor proteins.
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