Angiotensin II Type 2 Receptor–Bradykinin B ₂ Receptor Functional Heterodimerization
Population
PC12W cell membranes
Design
Preclinical
Authors
Discussion
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Member takes
Implication
May identify a novel hypertension target; leaves open translation from animal cells to human outcomes.
Structured PICO
P
Population
PC12W cell membranes
I
Intervention
Simultaneous activation and expression of Angiotensin II type 2 (AT2R) and bradykinin B2 (B2R) receptors
O
Outcome
Distance between AT2R and B2R and evidence of receptor heterodimerizationsurrogate
Demonstrates that AT2R and B2R form functional heterodimers to enhance NO production, identifying a potential therapeutic target for hypertension and cardiovascular diseases.
Cite This Study
Abadir et al. (2006) studied this question.