Key result
Higher malondialdehyde and lower superoxide dismutase levels were independently associated with concentric hypertrophy in patients with primary hypertension (MDA OR 3.669; SOD OR 0.796, P<0.001).
Why the study?
The study was conducted to investigate the relationship of superoxide dismutase (SOD) and malondialdehyde (MDA) levels with left ventricular geometry and function in patients with primary hypertension.
Are superoxide dismutase and malondialdehyde levels associated with left ventricular geometry and function in patients with primary hypertension?
Cross-Sectional (n=247)
Are superoxide dismutase and malondialdehyde levels associated with left ventricular geometry and function in patients with primary hypertension?
Odds Ratio: 3.669
p-value: p=<0.001
Oxidative stress markers SOD and MDA are independently associated with adverse left ventricular geometric changes in patients with primary hypertension.
SOD/MDA levels associate with LV geometry changes in PH; hypothesis-generating and should not yet alter practice.
INTRODUCTION: To investigate the relationship of superoxide dismutase (SOD) and malondialdehyde (MDA) levels with left ventricular geometry (LVG) and function in patients with primary hypertension (PH). METHODS: A total of 222 PH patients and 25 healthy control (HC)s were enrolled in this study. All subjects underwent echocardiography and blood biochemical examination. PH patients were divided into four groups based on Ganau classification: normal geometry (NG) group, concentric remodeling (CR) group, eccentric hypertrophy (EH) group, and concentric hypertrophy (CH) group. Pearson correlation analysis and logistic regression analysis were used to analyze the relationship between SOD and MDA with left ventricular structure and function. RESULTS: Compared to the HC, NG and CR groups, MDA level was higher while SOD level was lower in the EH and CH groups (all P < 0.001). SOD level was negatively correlated with IVSd, LVDd, LVPW, and global longitudinal strain (GLS), but positively correlated with LVEF. MDA level was positively correlated with IVSd, LVPW, and GLS, while negatively correlated with e'/a' and LVEF. SOD and MDA were independently associated with CR (OR = 0.970, P = 0.003; OR = 1.204, P = 0.043), EH (OR = 0.879, P < 0.001; OR = 2.197, P = 0.001) and CH (OR = 0.796, P < 0.001; OR = 3.669, P < 0.001). CONCLUSION: The SOD and MDA levels were correlated with LVG and function in PH patients. SOD and MDA may be important influencing factors of LVG change.
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Wei et al. (2022) conducted a cross-sectional in Primary hypertension (n=247). Superoxide dismutase (SOD) and malondialdehyde (MDA) levels vs. Healthy controls and normal geometry was evaluated on Concentric hypertrophy (CH) (OR 3.669, p=<0.001). Higher malondialdehyde and lower superoxide dismutase levels were independently associated with concentric hypertrophy in patients with primary hypertension (MDA OR 3.669; SOD OR 0.796, P<0.001).
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