Key result
Higher intracellular magnesium levels (>1.23 microg/mg protein) in stable CAD patients were associated with significantly greater functional capacity compared to lower levels (10.6 vs 8.9 METs, p<0.05).
Why the study?
Are higher intracellular magnesium levels associated with enhanced functional capacity in patients with stable coronary artery disease?
Cross-Sectional (n=42)
Are higher intracellular magnesium levels associated with enhanced functional capacity in patients with stable coronary artery disease?
Higher intracellular magnesium levels are associated with greater functional capacity in patients with stable coronary artery disease.
Hypothesis-generating for intracellular magnesium in stable CAD; prospective trials needed before any clinical consideration.
To determine whether increased intracellular levels of magnesium ([Mg]i) are associated with enhanced functional capacity, we performed symptom-limited exercise treadmill testing on 42 stable coronary artery disease (CAD) patients (37 men, 5 women, mean age 68 +/- 9 years). [Mg]i was found to be an independent and significant predictor of exercise duration (R = 0.31, p = 0.02) in a multivariate stepwise regression model. Patients with > normal [Mg]i of 1.23 microg/mg protein (n = 13) had a significantly greater mean functional capacity, measured in higher achieved metabolic equivalents (10.6 +/- 2.5 vs. 8.9 +/- 2.3, p < 0.05) and exercise duration (9.4 +/- 2.3 vs. 7.9 +/- 2.2 min, p < 0.05) compared to patients with [Mg]i </= the normal (n = 29). Thus, functional capacity is greater in stable CAD patients with higher [Mg]i, suggesting that magnesium may play a role in CAD pathophysiology, possibly via ventricular unloading.
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Shechter et al. (1998) conducted a cross-sectional in stable coronary artery disease (CAD) (n=42). Higher intracellular magnesium (>1.23 microg/mg protein) vs. Intracellular magnesium ≤1.23 microg/mg protein was evaluated on functional capacity (achieved metabolic equivalents) (p=<0.05). Higher intracellular magnesium levels (>1.23 microg/mg protein) in stable CAD patients were associated with significantly greater functional capacity compared to lower levels (10.6 vs 8.9 METs, p<0.05).
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