What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Atherosclerotic plaque in the carotid arteries (n=28). Intervention: Compound ultrasound strain imaging (CUSI) vs. Magnetic resonance imaging (MRI). Primary outcome: Difference in strain values across plaque categories (calcified, lipid, hemorrhagic, fibrous/aspecific) and for vulnerable versus stable plaques (p=<0.05).

November 19, 2024Ultrasound in Medicine & BiologyOpen Access

Ultrasound Strain Imaging for Characterizing Atherosclerotic Plaque in the Carotid Arteries of Asymptomatic Subjects

Q: What are the key findings of this study?

Compound ultrasound strain imaging (CUSI) successfully differentiated lipid from calcified plaques (p < 0.05) and vulnerable from stable plaques (p < 0.05) in asymptomatic individuals.

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Key result

Compound ultrasound strain imaging (CUSI) successfully differentiated lipid from calcified plaques (p < 0.05) and vulnerable from stable plaques (p < 0.05) in asymptomatic individuals.

Why the study?

Carotid MRI is limited by cost and procedure time, and compound ultrasound strain imaging (CUSI) required evaluation in transverse planes to determine if it can differentiate plaque composition in asymptomatic individuals with an increased cardiovascular risk profile.

Does compound ultrasound strain imaging (CUSI) differentiate plaque composition and vulnerability compared to MRI in asymptomatic individuals with increased cardiovascular risk?

Population

42 plaques in 28 asymptomatic participants with an increased cardiovascular risk profile

Comparison

Transverse compound ultrasound strain imaging vs MRI plaque classification

Design

Cross-sectional study

Authors

HHHendrik H.G. HansenMaastricht University Medical Centre ABAlies H M Bekkers IMInge C.L. van den MunckhofRadboud University Nijmegen

Discussion

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Implication

CUSI may enable non-invasive carotid plaque assessment; leaves open clinical replacement of MRI pending validation.

Study Design

Type

Cross-Sectional (n=28)

Structured PICO

Does compound ultrasound strain imaging (CUSI) differentiate plaque composition and vulnerability compared to MRI in asymptomatic individuals with increased cardiovascular risk?

Population

28 asymptomatic individuals with an increased cardiovascular risk profile (contributing 42 plaques) evaluated for carotid plaque composition.

Exposure

Compound ultrasound strain imaging (CUSI) in transverse imaging planes

Comparator

Magnetic resonance imaging (MRI) classification by an experienced neuroradiologist

Outcome

Strain differences across four plaque categories (calcified, lipid, hemorrhagic, fibrous/aspecific) and for vulnerable versus stable plaquessurrogate

Main Result

p-value: p=<0.05

Compound ultrasound strain imaging in transverse planes can non-invasively differentiate between stable and vulnerable carotid plaques in asymptomatic high-risk patients.

Cite This Study

Hansen et al. (2024) conducted a cross-sectional in Atherosclerotic plaque in the carotid arteries (n=28). Compound ultrasound strain imaging (CUSI) vs. Magnetic resonance imaging (MRI) was evaluated on Difference in strain values across plaque categories (calcified, lipid, hemorrhagic, fibrous/aspecific) and for vulnerable versus stable plaques (p=<0.05). Compound ultrasound strain imaging (CUSI) successfully differentiated lipid from calcified plaques (p < 0.05) and vulnerable from stable plaques (p < 0.05) in asymptomatic individuals.

synapsesocial.com/papers/6a96687a555aebb9fcbb728a https://doi.org/10.1016/j.ultrasmedbio.2024.10.009

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Ultrasound Strain Imaging for Characterizing Atherosclerotic Plaque in the Carotid Arteries of Asymptomatic Subjects

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Ultrasound Strain Imaging for Characterizing Atherosclerotic Plaque in the Carotid Arteries of Asymptomatic Subjects

Discussion

Member takes

Implication

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider