Immunologic Detection of Myoglobinuria After Cardiac Surgery

Article1 December 1967Immunologic Detection of Myoglobinuria After Cardiac SurgeryL. J. KAGENL. J. KAGENAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-6-1183 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMyoglobin, the low-molecular weight, heme-containing pigment protein of skeletal muscle, has been found in the urine of patients after a variety of types of muscle injury. In certain patients, as well as in experimental animals, renal damage and death due to renal failure have been the sequel to myoglobinuric states (1-5). In animal experiments this has been true after intravenous injection of myoglobin-containing solutions in the absence of muscle trauma.Myoglobin has been detected by a variety of chemical and physical methods reviewed recently (6) as well as by the use of antibody techniques (7-12). In general, immunologic methods allow...References1. 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To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: L. J. KAGENAffiliations: New York, New YorkFrom the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Edward Daniels Faulkner Arthritis Clinic, Presbyterian Hospital, New York, N. Y.This study was supported in part by research grant AM-04866-05, U. S. Public Health Service, Washington, D. C., and a grant from the John A. Hartford Foundation, New York, N. Y.Requests for reprints should be addressed to L. J. Kagen, M.D., Department of Medicine, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, N. Y. 10032. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe Crush Syndrome: A Complication of Urological SurgeryMyoglobinuria and Acute Renal FailureSerum myoglobin concentration as an index of myocardial damage after cardiac surgeryEditorial note Myoglobinemia in myocardial infarctionRapid renal clearance of immunoreactive canine plasma myoglobin.Radioimmunoassay for human myoglobin. Initial experience in patients with coronary heart disease.Serum myoglobin level as diagnostic test in patients with acute myocardial infarction.Human myoglobin: Preparation, quantitation and standardizationDünnschicht-Gelfiltration von Myoglobin und HämoglobinMyoglobinuriaMyoglobinemia and myoglobinuria in patients with myositisImmunofluorescent demonstration of myoglobin in the kidney 1 December 1967Volume 67, Issue 6Page: 1183-1189KeywordsHospital medicineMedical servicesMuscle proteinsMusclesRenal failureResearch grantsSkeletal musclesSurgeonsSurgeryUrine ePublished: 1 December 2008 Issue Published: 1 December 1967 PDF downloadLoading ...