Key result
In patients with hypothyroidism, pericardial effusion was the most common echocardiographic abnormality, and while some abnormalities reversed with thyroxin replacement, abnormal wall motion did not.
Why the study?
Does physiological thyroxin replacement improve echocardiographic abnormalities in patients with hypothyroidism?
Cross-Sectional (n=85)
Does physiological thyroxin replacement improve echocardiographic abnormalities in patients with hypothyroidism?
Hypothyroidism is associated with various echocardiographic abnormalities, most commonly pericardial effusion, some of which are reversible with thyroxin replacement.
Answers are grounded in this paper and cite their sources.
Wall motion abnormalities may persist after thyroxin in hypothyroidism; leaves open whether replacement fully reverses echocardiographic changes.
Cross-sectional echocardiography was used to identify and quantify different cardiac abnormalities in 85 patients with hypothyroidism. Pericardial effusion was the most common and was found in 32 patients (37.6%), while abnormal increase in left ventricular dimensions with impairment of function followed next in frequency (16.4%). Asymmetrical septal hypertrophy as well as segmental wall motion abnormality were each detected in 11.76%. Holosystolic prolapse of the mitral valve was present in only 4.7% of the cases. Different combinations of abnormalities were observed in a total of 22 patients (25.76%), and pericardial effusion was a constant finding. Some of the abnormalities were reversed with physiological thyroxin replacement, but abnormal wall motion remained unimproved.
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Nouh et al. (1991) conducted a cross-sectional in Hypothyroidism (n=85). Hypothyroidism and physiological thyroxin replacement was evaluated on Pericardial effusion. In patients with hypothyroidism, pericardial effusion was the most common echocardiographic abnormality, and while some abnormalities reversed with thyroxin replacement, abnormal wall motion did not.
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