Key result
Full replacement therapy linked to reversal of echocardiographic abnormalities in children with primary hypothyroidism.
Why the study?
Does full replacement therapy improve echocardiographic abnormalities in children with primary hypothyroidism?
Observational (n=11)
Does full replacement therapy improve echocardiographic abnormalities in children with primary hypothyroidism?
Thyroid replacement therapy reverses myopericardial abnormalities in children with primary hypothyroidism, demonstrating a response similar to that seen in adults.
Eleven children with primary hypothyroidism were studied by echocardiography. Eight patients had pericardial effusion. Systolic time intervals (preejection period-ejection time ratio and left ventricular isovolumic contraction time) were suggestive of abnormal myocardial function. Asymmetric septal hypertrophy without left ventricular out-flow obstruction (ventricular septal-left ventricular posterior wall diastolic thickness ratio, greater than 1.3) was present in two hypothyroid children. After full replacement therapy, these cardiac abnormalities reversed to normal. Our data suggest that the myopericardial response to hypothyroidism in children is similar to that seen in adults.
No takes yet. Share an insight, caveat, or question.
Zia Q. Farooki (1983) conducted an observational in Primary hypothyroidism (n=11). Full replacement therapy vs. Baseline (pre-treatment) was evaluated on Echocardiographic cardiac abnormalities (pericardial effusion, abnormal systolic time intervals, asymmetric septal hypertrophy). Full replacement therapy reversed echocardiographic abnormalities, including pericardial effusion and asymmetric septal hypertrophy, to normal in children with primary hypothyroidism.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: