Key result
Repetitive ischemia significantly delayed recovery of preload recruitable work area over the first 24 hours compared to a single occlusion (P<0.05).
Why the study?
Does repetitive reversible ischemia delay recovery of regional myocardial function compared to a single episode of ischemia in a canine model?
Population
8 conscious dogs instrumented with ultrasonic dimension transducers and left ventricular micromanometers
Comparison
Two 15-min left anterior descending coronary… vs A single 15-min LAD occlusion
Design
Preclinical, random sequence
Follow-up
24 h
Authors
Loading...
Suggests repetitive ischemia prolongs stunning in canines; leaves open translation to human ischemia-reperfusion syndromes.
RCT (n=8)
Random sequence
Does repetitive reversible ischemia delay recovery of regional myocardial function compared to a single episode of ischemia in a canine model?
p-value: p=<0.05
Repetitive episodes of reversible ischemia significantly delay the recovery of regional myocardial function and postischemic myocardial creep compared to a single ischemic episode.
Gall et al. (1993) conducted an RCT in Myocardial ischemia (n=8). Repetitive ischemia (two 15-min LAD occlusions) vs. Single 15-min LAD occlusion was evaluated on Recovery of preload recruitable work area (PRWA) over the first 24 h (p=<0.05). Repetitive ischemia significantly delayed recovery of preload recruitable work area over the first 24 hours compared to a single occlusion (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: