Key result
Provoked paroxysmal supraventricular tachycardia in 2 patients with Wolff-Parkinson-White syndrome resulted in a 10- to 20-fold increase in plasma hANP concentration.
Why the study?
Does provoked paroxysmal supraventricular tachycardia alter plasma hANP and arginine vasopressin levels in patients with Wolff-Parkinson-White syndrome?
Case Report (n=2)
Does provoked paroxysmal supraventricular tachycardia alter plasma hANP and arginine vasopressin levels in patients with Wolff-Parkinson-White syndrome?
Effect estimate: 10- to 20-fold increase
Polyuria during paroxysmal tachycardia in WPW syndrome is likely due to inhibition of arginine vasopressin release rather than the natriuretic effect of elevated hANP.
No takes yet. Share an insight, caveat, or question.
hANP surge during PSVT in WPW unlikely to explain polyuria; hypothesis-generating for AVP inhibition, needs prospective confirmation.
Kojima et al. (2008) conducted a case report in Wolff-Parkinson-White syndrome (n=2). Provoked paroxysmal supraventricular tachycardia vs. Baseline was evaluated on Plasma human atrial natriuretic polypeptide (hANP) concentration (10- to 20-fold increase). Provoked paroxysmal supraventricular tachycardia in 2 patients with Wolff-Parkinson-White syndrome resulted in a 10- to 20-fold increase in plasma hANP concentration.
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