Key result
Plasma atrial natriuretic polypeptide concentrations were elevated during supraventricular tachycardia and atrial flutter, and fell significantly after reversion to sinus rhythm.
Why the study?
Does reversion to sinus rhythm reduce plasma atrial natriuretic polypeptide concentrations in patients with paroxysmal supraventricular tachycardia or atrial flutter?
Population
30 patients, including 23 with paroxysmal supraventricular tachycardia and 7 with atrial flutter.
Comparison
Reversion to sinus rhythm vs During supraventricular tachycardia (baseline)
Design
Cohort
Follow-up
30 minutes after reversion
Authors
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May explain polyuria in SVT/flutter; hypothesis-generating for arrhythmia-related hormonal effects.
Observational (n=30)
Does reversion to sinus rhythm reduce plasma atrial natriuretic polypeptide concentrations in patients with paroxysmal supraventricular tachycardia or atrial flutter?
Plasma atrial natriuretic polypeptide levels rise during supraventricular tachycardia and fall rapidly after reversion to sinus rhythm, potentially explaining the polyuria often associated with these arrhythmias.
Oliver et al. (1988) conducted an observational in Paroxysmal supraventricular tachycardia and atrial flutter (n=30). Supraventricular tachycardia and atrial flutter vs. Sinus rhythm (post-reversion) was evaluated on Plasma concentrations of immunoreactive atrial natriuretic polypeptide. Plasma atrial natriuretic polypeptide concentrations were elevated during supraventricular tachycardia and atrial flutter, and fell significantly after reversion to sinus rhythm.
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