Key result
The presence of inactive epicardial patches significantly increased the mean defibrillation threshold energy by 49% to 97% for several nonthoracotomy lead configurations (P≤0.05).
Why the study?
Does the presence of inactive epicardial patches increase defibrillation threshold energy requirements with nonthoracotomy lead configurations in a canine model?
Population
16 dogs (weight 23.3 +/- 2.4 kg) undergoing ventricular fibrillation induction
Comparison
Presence of inactive epicardial 14-cm2 titanium… vs Defibrillation with no patches on the heart
Design
Preclinical
Authors
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May require adjusted ICD lead configurations in patients with prior patches; leaves open human translation and clinical impact.
Does the presence of inactive epicardial patches increase defibrillation threshold energy requirements with nonthoracotomy lead configurations in a canine model?
Effect estimate: 49% to 97% increase
p-value: p=≤0.05
Inactive epicardial patches, particularly over the left ventricle, significantly increase defibrillation energy requirements for nonthoracotomy lead configurations in a canine model.
Fotuhi et al. (1995) studied Ventricular fibrillation (n=16). Inactive epicardial patches vs. No patches on the heart was evaluated on Defibrillation threshold (DFT) energy (49% to 97% increase, p=≤0.05). The presence of inactive epicardial patches significantly increased the mean defibrillation threshold energy by 49% to 97% for several nonthoracotomy lead configurations (P≤0.05).
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