Key result
Enhanced bone mineral density in weight-bearing athletes compared to controls was dependent on VDR genotypes, specifically observed in those with the FF genotype (7.7% increase).
Why the study?
Does the vitamin D receptor (VDR) genotype influence the effect of impact loading on bone mineral density in young male athletes?
Cross-Sectional (n=212)
Does the vitamin D receptor (VDR) genotype influence the effect of impact loading on bone mineral density in young male athletes?
VDR FF genotype may enhance BMD response to impact loading in young male athletes; hypothesis-generating and requires prospective confirmation before clinical use.
Bone adaptation to exercise relies on exposures to impact loading in sports, but the ability of skeletal change seems to be highly variable among individuals. The present study was designed to investigate the association between a poly‐morphism in the vitamin D receptor (VDR) gene at the translation initiation site and impact loading on bone mineral density (BMD). Analysis of the VDR genotypes detected by endonuclease FokI (FF, Ff, and ff) and measurement of total body BMD (TBMD) were performed in 212 young males; 84 athletes were involved in weight‐bearing sports, 48 in competitive swimming, and 80 non‐athletic controls. The differences in TBMD between athletes and controls de‐pended on the VDR genotypes; enhanced BMD in weight‐bearing athletes was found in FF (7.7%, p
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Nakamura et al. (2002) conducted a cross-sectional in Healthy (n=212). Impact loading sports and VDR genotypes vs. Non-athletic controls was evaluated on Total body bone mineral density (TBMD). Enhanced bone mineral density in weight-bearing athletes compared to controls was dependent on VDR genotypes, specifically observed in those with the FF genotype (7.7% increase).
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