Key result
VDR ApaI genotype accounts for ~18% of variance in musculoskeletal injury severity, unlike BsmI or FokI.
Why the study?
Are Vitamin D receptor (VDR) gene polymorphisms associated with the incidence and severity of musculoskeletal injuries in professional football players?
Observational (n=54)
No
Are Vitamin D receptor (VDR) gene polymorphisms associated with the incidence and severity of musculoskeletal injuries in professional football players?
p-value: p=0.254
The ApaI polymorphism of the vitamin D receptor gene may influence the severity of muscle injuries in elite male football players.
ApaI genotype was associated with injury severity; hypothesis-generating in this cohort and requires prospective validation before clinical use.
The aim of the present study was to investigate the association between vitamin D receptor (VDR) gene polymorphisms and musculoskeletal injury (MI) in elite football players. In total, 54 male professional football players were recruited from an official Italian professional championship team between 2009 and 2013. The cohort was genotyped for the ApaI, BsmI and FokI polymorphisms and MI data were collected over four football seasons. No significant differences were identified among the genotypes in the incidence rates or severity of MI (P=0.254). In addition, no significant associations were observed between VDR polymorphisms and MI phenotypes (P=0.460). However, the results of the casewise multiple regression analysis indicated that the ApaI genotypes accounted for 18% of injury severity (P=0.002). Therefore, while the BsmI and FokI polymorphisms did not appear to be associated with the severity or incidence of MI, the ApaI genotypes may have influenced the severity of muscle injury in top‑level football players.
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Massidda et al. (2015) conducted an observational in Musculoskeletal injuries (n=54). VDR gene polymorphisms (ApaI, BsmI, FokI) vs. Wild-type or alternative genotypes was evaluated on Incidence and severity of musculoskeletal injuries (p=0.254). VDR gene polymorphisms BsmI and FokI were not associated with musculoskeletal injury incidence or severity, but the ApaI genotype accounted for 18% of the variance in injury severity.
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