Key result
A stable infectious cDNA clone of coxsackievirus B5 was successfully constructed, yielding a rescued virus with biological characteristics and virulence comparable to the parental strain.
The successful construction of an infectious cDNA clone of CV-B5 provides a reliable tool for future virological studies, as the rescued virus exhibits identical characteristics to the parental strain.
Provides validated reverse-genetics tool for CV-B5; leaves open applications in pathogenesis and intervention studies.
• An infectious cDNA clone of CV-B5 was constructed. • The rescued and parental virus possessed similar biological characteristics. • The virulence of the rescued virus was similiar to that of the parental virus. • Viral distribution and tissue tropism of those two viruses were in agreement.
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Song et al. (2022) conducted a letter in Coxsackievirus B5 infection. Rescued CV-B5 virus from cDNA clone vs. Parental CV-B5 virus was evaluated on Viral characteristics and pathogenicity (LD50). A stable infectious cDNA clone of coxsackievirus B5 was successfully constructed, yielding a rescued virus with biological characteristics and virulence comparable to the parental strain.
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