February 1, 2015EuroIntervention
Incidence, characteristics and functional implications of cerebral embolic lesions after the MitraClip procedure
Key result
The MitraClip procedure resulted in newly acquired cerebral microembolic lesions in 85.7% of high-risk patients, with device time identified as an independent predictor of the number of new lesions (p=0.003).
Why the study?
Does the MitraClip procedure cause cerebral embolic lesions and affect cognitive function in high-risk patients?
Structured PICO
Does the MitraClip procedure cause cerebral embolic lesions and affect cognitive function in high-risk patients?
P
Population
27 high-risk patients undergoing the MitraClip procedure, evaluated with cerebral MRI and cognitive testing before and 3 days after the intervention.
I
Intervention
MitraClip procedure
O
Outcome
Incidence of cerebral embolic lesions on diffusion-weighted MRI and neurocognitive function assessed by Montreal Cognitive Assessment (MoCA) questionnaire at median 3 days post-proceduresafety
While the MitraClip procedure results in new ischemic cerebral lesions in the vast majority of patients, these lesions appear to have no significant short-term impact on global cognitive function.
Authors
Discussion
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Implication
New lesions occur in most MitraClip patients and rise with device time; leaves open long-term cognitive effects and need for protection strategies.
Cite This Study
Blazek et al. (2015) studied High surgical risk requiring MitraClip (n=27). MitraClip procedure was evaluated on Newly acquired microembolic lesions on MRI. The MitraClip procedure resulted in newly acquired cerebral microembolic lesions in 85.7% of high-risk patients, with device time identified as an independent predictor of the number of new lesions (p=0.003).