Key result
Mitral valve reconstruction techniques evolved from mainly resection maneuvers to predominant use of artificial chordae, with 5-year survival improving to 80% in 2015-2019 compared to 66% in 2004-2009.
Why the study?
Mitral valve reconstruction techniques and strategies have changed over the years, prompting an evaluation of procedural characteristics and outcomes in an all-comer, non-selected cohort.
How have procedural characteristics and outcomes of mitral valve reconstruction changed over a 15-year period?
Cohort (n=738)
No
How have procedural characteristics and outcomes of mitral valve reconstruction changed over a 15-year period?
Answers are grounded in this paper and cite their sources.
Over a 15-year period, mitral valve reconstruction techniques evolved from predominantly resection to the use of artificial chordae, which was associated with improved long-term survival.
OBJECTIVE: Mitral valve reconstruction (MVR) is one of the cardiosurgical procedures which cannot be substituted by any intervention owing to the quality of the quasi-anatomical, physiological repair. However, technique and strategies have changed over the years. We looked at procedural characteristics and outcome in an all-comer, non-selected cohort of patients. METHODS: 738 out of 1.977 patients were retrospectively analyzed receiving MVR with and without concomitant procedures. The cohort was divided into three periods. P1: 2004-2009 (134 pts.); P2: 2010-2014 (294 pts.), and P3: 2015-2019 (310 pts.). RESULTS: Early mortality increased from P1 to P2 and decreased from P2 to P3 (9% P1, 13% P2, 10% P3). All patients received an annuloplasty-ring. In P1 resection measures dominated. In P3 artificial chordae were dominant. Age, BMI, and risk scores correlated with early mortality. Survival rates were 66% (5-years), 55% (10-years), 44% (15-years) in P1, 63% (5-years), 50% (10-years) in P2, and 80% (5-years) in P3. Odds ratio for reduced long-term survival were concomitant venous only bypass surgery (10-years 2,701, p = 0.026). 10-year survival was positively influenced by isolated MVR (0.246, p = 0.001), concomitant isolated arterial bypass (IMA) (0.153, p = 0.051), posterior leaflet measure (0.178, p<0.001), and use of artificial chordae (5-years 0.235, p<0.001). CONCLUSION: Indication for ring implantation remained mandatory while preference changed alongside improved designs. Procedural characteristics changed from mainly resection maneuvers to predominant use of artificial chordae. Long-term results were negatively influenced by co-morbidities and positively influenced by posterior leaflet repair and artificial chordae. MVR underwent a qualitative evolution and remains a valuable cardiosurgical procedure.
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Motazedian et al. (2022) conducted a cohort in Mitral valve regurgitation (n=738). Mitral valve reconstruction (evolution of techniques) vs. Historical periods (2004-2009 vs 2010-2014 vs 2015-2019) was evaluated on All-cause mortality (5-year survival) (p=<0.001). Mitral valve reconstruction techniques evolved from mainly resection maneuvers to predominant use of artificial chordae, with 5-year survival improving to 80% in 2015-2019 compared to 66% in 2004-2009.
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