Key result
High-dose fluconazole administration in a 25-year-old woman with a prolonged QT interval was associated with the development of torsades de pointes.
Why the study?
Does high-dose fluconazole induce torsades de pointes in patients with prolonged QT interval?
Population
A 25-year-old woman hospitalized for worsening endocarditis with a prolonged QT interval at baseline and…
Design
Case_report
Authors
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Supports caution with high-dose fluconazole in prolonged QT patients; Level 5 case leaves open causality and generalizability.
Case Report (n=1)
Does high-dose fluconazole induce torsades de pointes in patients with prolonged QT interval?
High-dose fluconazole can induce torsades de pointes, highlighting the need for caution in patients with known risk factors such as a prolonged QT interval.
Khazan et al. (2002) conducted a case report in Endocarditis and fungemia (n=1). Fluconazole was evaluated on Torsades de pointes. High-dose fluconazole administration in a 25-year-old woman with a prolonged QT interval was associated with the development of torsades de pointes.
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