Key result
Among 337 individuals, 37% of those with fatty liver did not have metabolic syndrome, prediabetes, or diabetes, supporting the existence of a metabolically benign fatty liver state.
Accumulation of fat in the visceral cavity and liver, accompanied by inflammation, is responsible for the genesis of insulin resistance, a common risk factor for type 2 diabetes and cardiovascular disease.
Identifies metabolically benign fatty liver in over one-third; leaves open its long-term cardiometabolic implications.
The epidemics of the major metabolic diseasestype 2 diabetes and cardiovascular disease areincreasing worldwide and much effort is beingundertaken to understand the pathogenesis of these conditions. Both type 2 diabetes and cardiovascular disease share insulin resistance as a common and impor-tant risk factor in their natural history. It is now widely accepted that organ cross talk harbors many critical clues that help to better understand the pathogenesis of insulin resistance. In this respect, several studies recently showed that not the increase in body fat mass per se, but the ac-cumulation of fat in the visceral cavity and particularly in the liver, which are conditions commonly accompanied by inflammatory processes, are responsible for the genesis of insulin resistance (1–4). NONALCOHOLIC FATTY LIVER DISEASE Prevalence, pathogenesis, and progression. The prev-alence of nonalcoholic fatty liver disease (NAFLD) has in-
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Stefan et al. (2011) conducted a review in Nonalcoholic fatty liver disease (n=337). Hepatic fat accumulation was evaluated. Among 337 individuals, 37% of those with fatty liver did not have metabolic syndrome, prediabetes, or diabetes, supporting the existence of a metabolically benign fatty liver state.
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