Why the study?
Labetalol and nitroglycerine are commonly used to control blood pressure in hypertensive crises, but head-to-head comparisons between them are lacking.
Does intravenous labetalol improve the rapidity of blood pressure control compared to intravenous nitroglycerine in patients with hypertensive crises?
Does intravenous labetalol improve the rapidity of blood pressure control compared to intravenous nitroglycerine in patients with hypertensive crises?
Intravenous labetalol provides more rapid blood pressure control than intravenous nitroglycerin in patients with hypertensive crises, without increasing side effects.
May support preferring labetalol for faster BP control in crises; leaves open confirmation in larger randomized trials.
Hypertensive crises is still a major public health problem, causing end organ damage like myocardial infarction, stroke, and renal failure. Labetalol and nitroglycerine are among the two most commonly used medicine to control the blood pressure, but there is no head to head comparison between these two medicines. This was a prospective randomized non-blinded study which included 50 patients of hypertensive crises, out which 25 patients received intravenous labetalol and 25 patients received intravenous nitroglycerine. We found that labetalol controlled the blood pressure more rapidly in comparison to nitroglycerine, without causing any extra side effect.
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Malik et al. (2022) studied this question.
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