Why the study?
Does continuous ambulatory peritoneal dialysis significantly alter the clearance of quinidine in a patient?
Does continuous ambulatory peritoneal dialysis significantly alter the clearance of quinidine in a patient?
Quinidine dosage adjustment is likely unnecessary for patients undergoing continuous ambulatory peritoneal dialysis, as dialysis clearance accounts for a negligible fraction of total body clearance.
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Minimal quinidine removal by peritoneal dialysis in this case; leaves open dosing implications for broader CAPD populations.
The clearance of quinidine was evaluated in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD). The dialysis clearance of quinidine was 0.793 ml/min which represented only 0.61% of the total body clearance (154.21 ml/min) of the drug. The elimination half-life of quinidine was 5.44 hours. Based on our results, dosage adjustment of quinidine does not appear to be necessary for patients undergoing CAPD.
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Chin et al. (1981) studied this question.
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