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February 2, 2016Seminars in Thrombosis and Hemostasis

The review provides an overview of the current treatment strategies for VWD and AVWS in developed countries, including VWF/FVIII replacement and desmopressin, and notes that recombinant VWF is undergoing clinical trials.

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Population

Patients with congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS)

Design

Review

Authors

LPLeonardo PasalicEFEmmanuel J. FavaloroJCJennifer Curnow

Discussion

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Overview

VWF replacement remains first-line for VWD/AVWS bleeding prevention; leaves open optimal regimens and non-replacement strategies.

Structured PICO

P
Population
Patients with congenital von Willebrand disease (VWD) and acquired von Willebrand syndrome (AVWS)
I
Intervention
Replacement of von Willebrand factor (VWF) and/or factor VIII (FVIII) using concentrates, desmopressin, and adjunct therapies like antifibrinolytics
O
Outcome
Protection against bleeding

This review summarizes current standard-of-care treatments for von Willebrand disease, highlighting the primary role of VWF and FVIII replacement therapies to prevent bleeding.

Cite This Study

Pasalic et al. (2016) studied this question.

synapsesocial.com/papers/6a968c5896bab72bf50e2e0bhttps://doi.org/10.1055/s-0035-1569070
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Also Consider

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  1. 1Targeting von Willebrand disease: the current status and future directions of management therapies2023 · 2 citations
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  4. 4Pharmacokinetics-based clinical management of acquired von Willebrand syndrome: a case report2018 · 2 citations
  5. 5Therapeutic approaches to acquired von Willebrand syndrome2000 · 37 citations