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January 1, 2018Journal of Blood MedicineOpen Access

Pharmacokinetics-based clinical management of acquired von Willebrand syndrome: a case report

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Why the study?

Does pharmacokinetics-based dosing of VWF/FVIII concentrate improve clinical management in patients with acquired von Willebrand syndrome undergoing surgery?

Population

Patient with acquired von Willebrand syndrome (AVWS) undergoing surgery

Design

Case_report

Authors

CBCandice BaldeoCRCandido E. RiveraHTHan W. Tun

Discussion

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Overview

May support PK-guided dosing in AVWS surgery; hypothesis-generating and requires prospective validation.

Structured PICO

Does pharmacokinetics-based dosing of VWF/FVIII concentrate improve clinical management in patients with acquired von Willebrand syndrome undergoing surgery?

P
Population
Patient with acquired von Willebrand syndrome (AVWS) undergoing surgery
I
Intervention
Pharmacokinetics-based calculation of loading and maintenance doses of VWF/FVIII concentrate
O
Outcome
Normalization of plasma levels of von Willebrand factor (VWF) and factor VIII (FVIII)surrogate

Pharmacokinetics-based dosing of VWF/FVIII concentrate may optimize treatment and avoid unnecessary infusions in patients with acquired von Willebrand syndrome undergoing surgery.

Cite This Study

Baldeo et al. (2018) studied this question.

synapsesocial.com/papers/6a968ea0f69cd3f6920208c6https://doi.org/10.2147/jbm.s152663
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Treatment of von Willebrand Disease2016 · 66 citations
  2. 2<scp>VON</scp> W<scp>ILLEBRAND</scp> F<scp>ACTOR</scp><scp>AND</scp><scp>VON</scp> W<scp>ILLEBRAND</scp> D<scp>ISEASE</scp>2001 · 51 citations
  3. 3Treatment of patients with von Willebrand disease2011 · 16 citations
  4. 4Targeting von Willebrand disease: the current status and future directions of management therapies2023 · 2 citations
  5. 5Diagnosis and management of von Willebrand disease1999 · 31 citations