Factor VIII/von Willebrand factor concentrate can provide effective hemostasis in patients with type 2B von Willebrand disease who develop severe refractory thrombocytopenia post-surgery and are alloimmunized to platelets.
A case of a severe thrombocytopenia occurring in a patient with type 2B von Willebrand disease following an esophagectomy is described. As platelet transfusions were ineffective due to alloimunization, effective hemostasis was achieved only with the factor VIII/von Willebrand factor concentrate Haemate P.
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Massimo Franchini (2006) studied this question.
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