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January 1, 2004Thrombosis and HaemostasisOpen Access

Dysfunctional platelet membrane receptors: from humans to mice

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Population

Mouse models of hemostasis and thrombosis (knockout mice missing key platelet receptors) and human platelets

Design

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Authors

JWJerry WareBoston University

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Overview

Mouse-human platelet differences warrant clinical caution in extrapolating knockout phenotypes; leaves open need for human-specific thrombosis models.

Structured PICO

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Population
Mouse models of hemostasis and thrombosis (knockout mice missing key platelet receptors) and human platelets

This review highlights the utility and limitations of mouse models with targeted platelet receptor deletions for studying hemostasis and thrombosis.

Cite This Study

Jerry Ware (2004) studied this question.

synapsesocial.com/papers/6a968dcb33d7b00ae7bb86e3https://doi.org/10.1160/th04-05-0308
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