Why the study?
To highlight thyrotoxicosis as a cause of hypokalaemic periodic paralysis, particularly in individuals of Asian ethnicity.
Thyrotoxic periodic paralysis should be considered in young Asian males presenting with sudden muscle weakness and hypokalemia, requiring prompt potassium replacement and hyperthyroidism management.
Hypokalaemic periodic paralysis (HPP) is a rare disorder characterized by episodic attacks of muscle weakness and hypokalaemia. Numerous factors contributing to HPP have been identified, encompassing both hereditary and familial origins as well as acquired factors. In this context, we highlight thyrotoxicosis causing HPP. We present a case of a 40-year-old Asian individual who presented with episodes of sudden onset bilateral proximal limb weakness and palpitations. Laboratory investigations revealed severe hypokalaemia (serum potassium: 1.8 mmol/L). Immediate potassium replacement therapy alleviated symptoms. Further evaluation revealed a new diagnosis of hyperthyroidism, with subsequent treatment initiated (carbimazole and propranolol) preventing recurrence of symptoms. This case highlights the importance of recognizing HPP as a potential manifestation of thyroid dysfunction, particularly in individuals of Asian ethnicity.
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Hussain et al. (2023) studied this question.
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