Why the study?
Existing ARDS risk prediction models rely predominantly on clinical and physiological parameters, highlighting a need for models incorporating proteomic biomarkers to identify patients predisposed to early ARDS.
Elevated levels of TXNDC5, CTSL, and NPC2 at the end of cardiopulmonary bypass may serve as early predictive biomarkers for the development of CPB-ARDS.
May aid early ARDS risk stratification; leaves open prospective validation before clinical use.
The identification of individuals at heightened risk of early acute respiratory distress syndrome (ARDS) presents a pivotal challenge in the effective prevention and clinical management of this condition.There is a pressing need to delve into the development of risk prediction models tailored specifically for ARDS, with the primary objective of furnishing clinicians with the means to discern cohorts predisposed to its early onset [1,2] .Notably, extant literature pertaining to ARDS prognostication, exemplified by the Lung Injury Prediction Score (LIPS), Surgical Lung Injury Prediction (SLIP), and SLIP2, predominantly relies on clinical and physiological parameters for risk stratification, thereby underscoring a notable absence in the incorporation of biomarkers [3][4][5] .As the principal investigative unit affiliated with the Key Laboratory of Anesthesiology and Resuscitation (Huazhong University of Science and Technology), Ministry of Education, our research endeavors are centered on the comprehensive examination of perioperative organ damage, with a particular emphasis on injuries affecting the cardiovascular, pulmonary, and cerebral systems.Consequently, we initiated three prospective nested cohorts at Union Hospital of Tongji Medical College Hospital to identify proteomic biomarkers and develop an early prediction model for cardiopulmonary bypassassociated acute respiratory distress syndrome (CPB-ARDS) [6] .Higher levels of three proteins, namely thioredoxin domain containing 5 (TXNDC5), cathepsin L (CTSL), and NPC intracellular cholesterol transporter 2 (NPC2), were observed in CPB-ARDS patients at the end of CPB.Eventually, a stepwise logistic regression algorithm (SLR) was employed to integrate protein
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Wang et al. (2024) studied this question.
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