Population
7 germ-free piglets (Groot Yorkshire 9 [Cof-ok 9 Large White]), 3-week-old
Comparison
Oral infection with virulent rotavirus vs Uninfected germ-free piglets (n=3)
Design
Preclinical
Follow-up
18 hours
Authors
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These piglet transcriptional changes warrant no clinical action; leaves open whether interferon genes drive human rotavirus disease.
Oral rotavirus infection in germ-free piglets induces early transcriptional changes in the jejunum, including up-regulation of interferon-regulated genes like guanylate binding protein 2.
Hulst et al. (2008) studied this question.
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