Population
Swine kidney cells (SK6) and insect cells expressing baculovirus vector
Comparison
Classical swine fever virus mutant with… vs Intact E(rns) / parent CSFV strain C
Design
Preclinical
Authors
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E(rns) RNase may enable CSFV persistence by blocking apoptosis; animal data leaves open in vivo roles and control strategies.
The RNase activity of CSFV envelope protein E(rns) prevents apoptosis and cytopathic effects in host cells, potentially facilitating viral persistence.
Hulst et al. (1998) studied this question.
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