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March 6, 2009Journal of VirologyOpen Access

Mutation of Cysteine 171 of Pestivirus ErnsRNase Prevents Homodimer Formation and Leads to Attenuation of Classical Swine Fever Virus

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Population

Pigs and tissue culture models infected with classical swine fever virus

Comparison

Mutation or deletion of cysteine 171 of the E… vs Parental (wild-type) viruses

Design

Preclinical

Authors

BTBirke Andrea TewsFriedrich-Loeffler-InstitutESEva-Maria SchürmannFriedrich-Loeffler-InstitutGMGregor MeyersFriedrich-Loeffler-Institut

Discussion

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Implication

E(rns) dimerization may contribute to CSFV virulence in pigs; hypothesis-generating for live-attenuated vaccine design.

Structured PICO

P
Population
Pigs and tissue culture models infected with classical swine fever virus
I
Intervention
Mutation or deletion of cysteine 171 of the E(rns) RNase
C
Comparator
Parental (wild-type) viruses
O
Outcome
Homodimer formation and viral attenuation in pigssurrogate

Mutation of cysteine 171 in the E(rns) RNase of classical swine fever virus prevents homodimer formation and attenuates the virus in pigs, suggesting a role in virulence.

Cite This Study

Tews et al. (2009) studied this question.

synapsesocial.com/papers/6a7c00441f8f1eb7b8ed4e2chttps://doi.org/10.1128/jvi.01710-08
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