Key result
A protocol-based strategy for early intensive lipid-lowering therapy improved achievement of LDL-C <70 mg/dL at 6 months compared to standard care (86.4% vs 73.7%; P=0.005).
Why the study?
Timely implementation of guideline-recommended intensive lipid-lowering therapy and achievement of LDL-C targets remain suboptimal in routine clinical practice after ACS.
Does a protocol-based implementation strategy improve achievement of LDL-C <70 mg/dL at 6 months in patients with acute coronary syndrome?
RCT (n=329)
1:1 cluster-randomized
Yes
Does a protocol-based implementation strategy improve achievement of LDL-C <70 mg/dL at 6 months in patients with acute coronary syndrome?
Captured external expert commentary on this paper, strongest first. Original sources are linked where available.
“These findings support a structured, protocol-based care pathway as a practical and scalable approach to improving the implementation and consistency of guideline-directed lipid management in routine clinical practice after ACS.”
A protocol-based implementation strategy for early intensive lipid-lowering therapy significantly improves the achievement of guideline-recommended LDL-C targets after acute coronary syndrome.
BACKGROUND: Although guideline-recommended intensive lipid-lowering therapy (LLT) reduces recurrent cardiovascular events after acute coronary syndrome (ACS), timely implementation of intensive LLT and achievement of low-density lipoprotein cholesterol (LDL-C) target remain suboptimal in routine clinical practice. OBJECTIVES: The purpose of this study was to determine whether a protocol-based implementation strategy improves timely achievement of guideline-recommended LDL-C target after ACS. METHODS: We conducted a cluster-randomized trial involving patients with ACS. Ten centers were randomly assigned 1:1 to protocol-based or standard lipid management. In the protocol-based group, LLT was initiated or intensified during the index hospitalization according to a prespecified algorithm based on baseline LLT status and LDL-C levels using high-intensity statins, ezetimibe, and PCSK9 inhibitors. LDL-C was reassessed at 4 weeks, with treatment escalation when indicated. In the protocol-based group, an LDL-C level of approximately 55 mg/dL was used as the protocol-specified operational threshold for intensification, whereas LDL-C <70 mg/dL was the treatment goal in both groups. The primary and key secondary endpoints were achievement of LDL-C <70 mg/dL and <55 mg/dL at 6 months, respectively. RESULTS: Between November 2024 and July 2025, 330 patients were enrolled, and 329 patients comprised the study population after 1 patient withdrew consent. The primary efficacy analysis included 315 patients with complete 6-month LDL-C data. Baseline characteristics were balanced between groups. The mean age was 69 years, 18% were women, and the median LDL-C level was 110 mg/dL. At 6 months, LDL-C <70 mg/dL was achieved in 86.4% vs 73.7% (between-group difference, 12.6 percentage points [95% CI: 3.8-21.5 percentage points]; P = 0.005); the corresponding difference was 12.8 percentage points (95% CI: -2.0 to 27.6 percentage points; P = 0.08) in a hospital-level sensitivity analysis. Similar findings were observed for LDL-C <55 mg/dL (60.8% vs 34.5%; between-group difference, 26.3 percentage points [95% CI: 18.5-34.0 percentage points]; P < 0.001). At 6 months, use of high-intensity statins, ezetimibe, and PCSK9 inhibitors was higher in the protocol-based group. CONCLUSIONS: A protocol-based implementation strategy for early intensive LLT significantly improved achievement of the guideline-recommended LDL-C target after ACS. These findings support a structured, algorithm-based care pathway to facilitate timely initiation and intensification of LLT and improve implementation of guideline-recommended lipid management in routine clinical practice. (Brief and Protocol-Based Intensive Lipid Management in Patients with Acute Coronary Syndrome; jRCT1020240029).
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Oyama et al. (2026) conducted an RCT in Acute Coronary Syndrome (n=329). Protocol-based implementation strategy for early intensive lipid-lowering therapy vs. Standard lipid management was evaluated on Achievement of LDL-C <70 mg/dL at 6 months (difference 12.6 percentage points, 95% CI 3.8-21.5, p=0.005). A protocol-based strategy for early intensive lipid-lowering therapy improved achievement of LDL-C <70 mg/dL at 6 months compared to standard care (86.4% vs 73.7%; P=0.005).
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