Short isocapnic hyperoxia affects indices of vascular remodeling and intercellular adhesion molecules in healthy men

Figures

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  Figure 1. Venous plasma levels of ICAM-1 (A), VCAM-1 (B), and P-selectin (C) in healthy men (n=8) at normoxia (21% O2) and during hyperoxia (100% O2). Data are reported as means±SD. *P<0.05 vs normoxia (Wilcoxon signed-rank test). ICAM-1: intercellular adhesion molecule 1; VCAM-1: vascular cell adhesion molecule 1.

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  Figure 2. Venous plasma MMP-9 activity (A), TIMP-1 levels (B), and net MMP-9 activity (C) in healthy men (n=10) exposed to normoxia (21% O2) and hyperoxia (100% O2). Data are reported as means±SD. *P<0.05 vs normoxia (Wilcoxon signed-rank test). MMP-9, matrix metalloproteinase-9; TIMP-1: tissue inhibitor of metalloproteinase 1.

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  Figure 3. Hyperoxia induces activation of the endothelium via increased ICAM-1 expression and stimulates the extracellular matrix dysregulation characterized by increased TIMP-1 levels and reduced MMP-9 activity. ICAM-1: intercellular adhesion molecule 1; MMP-9: matrix metalloproteinase-9; TIMP-1: tissue inhibitor of metalloproteinase 1.