Why the study?
Does 100% oxygen breathing alter hemodynamic parameters and biochemical markers of free radical production in healthy young male volunteers?
Population
29 healthy young male volunteers
Comparison
100% oxygen breathing for 1 hour vs Medical air
Design
RCT, randomized crossover design, double-blind, placebo-controlled
Follow-up
1 hour
Authors
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Advises caution with unnecessary 100% oxygen even in healthy subjects; extends RCT evidence on its vascular effects to young males.
Does 100% oxygen breathing alter hemodynamic parameters and biochemical markers of free radical production in healthy young male volunteers?
In healthy young men, 100% oxygen breathing increases peripheral vascular resistance and reduces heart rate and forearm blood flow, but does not affect blood pressure, free radical injury markers, or nitroglycerin response.
Milone et al. (1999) studied this question.
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