March 29, 2010Heart
Potentially detrimental cardiovascular effects of oxygen in patients with chronic left ventricular systolic dysfunction
Why the study?
Does oxygen alter haemodynamic and neurohumoral parameters in men with heart failure and left ventricular systolic dysfunction?
Population
13 men with heart failure and left ventricular systolic dysfunction (LVSD) at rest
Comparison
Oxygen vs Medical air
Design
RCT, randomised crossover, double-blind, placebo-controlled
Authors
Discussion
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Implication
High-flow oxygen reduces cardiac output in stable LVSD; challenges routine use and extends concerns about potential harm in decompensated heart failure.
Structured PICO
Does oxygen alter haemodynamic and neurohumoral parameters in men with heart failure and left ventricular systolic dysfunction?
P
Population
13 men with heart failure and left ventricular systolic dysfunction (LVSD) at rest
I
Intervention
Oxygen (40% and high concentration via Hudson non-rebreathing mask)
C
Comparator
Medical air
O
Outcome
Haemodynamic and neurohumoral effects (cardiac output, heart rate, systemic vascular resistance, forearm blood flow, natriuretic peptides)surrogate
High-concentration inhaled oxygen significantly reduces cardiac output and heart rate in men with stable LVSD, suggesting potential harm in decompensated heart failure.
Cite This Study
Balmain et al. (2010) studied this question.