Why the study?
Does hyperoxia alter cardiac index or systemic vascular resistance in patients with fixed heart rates via permanent pacemakers?
Population
9 patients with permanent pacemakers paced at a fixed rate
Comparison
Oxygen (inspired O2 fraction 0.80) vs Medical air (inspired O2 fraction 0.21)
Design
RCT, randomised, double-blind
Authors
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Hyperoxia leaves cardiac index unchanged in fixed-rate paced patients; confirms prior CO reductions are SVR-mediated, not direct myocardial effects.
Does hyperoxia alter cardiac index or systemic vascular resistance in patients with fixed heart rates via permanent pacemakers?
Hyperoxia does not have direct myocardial depressant effects; previously reported reductions in cardiac output are likely secondary to increased systemic vascular resistance.
Anderson et al. (2009) studied this question.
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