Why the study?
Does 100% oxygen breathing alter hemodynamic parameters, biochemical markers of free radical injury, or responses to nitroglycerin in healthy male volunteers?
Population
29 healthy male volunteers (young adults)
Comparison
100% oxygen exposure for 1 hour vs Medical air
Design
RCT, randomized crossover design, double-blind, placebo-controlled
Follow-up
1 hour
Authors
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May warrant caution with routine hyperoxia due to vasoconstriction; confirms hemodynamic effects independent of free radicals or nitroglycerin blunting.
Does 100% oxygen breathing alter hemodynamic parameters, biochemical markers of free radical injury, or responses to nitroglycerin in healthy male volunteers?
In healthy young men, 100% oxygen breathing increases peripheral vascular resistance and reduces heart rate and forearm blood flow without altering blood pressure, free radical markers, or nitroglycerin responsiveness.
Milone et al. (1999) studied this question.
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