Why the study?
Do antithrombotic drugs increase the risk of hemorrhagic stroke in the general population?
Do antithrombotic drugs increase the risk of hemorrhagic stroke in the general population?
This commentary highlights that while warfarin increases the risk of hemorrhagic stroke, aspirin may surprisingly decrease the frequency of subarachnoid hemorrhage, though further characterization of patient risk factors is needed.
examined the risk of hemorrhagic stroke in patients treated with antithrombotics.While warfarin increased the risk of both intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), aspirin did not influence the risk of ICH and surprisingly decreased the frequency of SAH.The authors did not distinguish between SAH where an aneurysm was identified vs SAH where no aneurysm was found.This would have been useful as previous studies have indicated that aspirin may protect against aneurysm rupture. 2 In addition, the highest risk of ICH was found in the short-duration group of warfarin users.This may be due to maintaining a balanced control of anticoagulation at the beginning of the treatment.Similar risk has been observed in recent trials comparing rivaroxaban to warfarin. 3 It would be interesting to evaluate some characteristics of the patients' international normalized ratio trend-age or concomitant hypertension-to verify other predisposing factors vs the HAS-BLED score.
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Simone Vidale (2014) conducted a letter in Hemorrhagic stroke. Antithrombotic drugs (warfarin and aspirin) was evaluated on Hemorrhagic stroke (intracerebral hemorrhage and subarachnoid hemorrhage).
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